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<article-title>The use of the Transnasal implant associated with the
zygomatic implants in the treatment of atrophic maxilla: A Case
Report</article-title>
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<contrib-group>
<contrib contrib-type="author">
<string-name>Pedro Henrique da Hora Sales
<ext-link ext-link-type="uri" xlink:href="https://orcid.org/0000-0002-5522-1121"></ext-link></string-name>
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<contrib contrib-type="author">
<string-name>Guilherme Costa do Amaral</string-name>
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<abstract>
<p><bold>Introduction:</bold> Rehabilitation of atrophic maxillae can be
a real challenge, even for experienced surgeons. The search for faster
and less morbid treatments, with the possibility of immediate loading,
has led surgeons to apply bone anchoring techniques, with longer
implants, anchored in areas further away from the alveolar ridge.
<bold>Objective:</bold> The objective of this article is to describe a
case report of rehabilitation of atrophic maxilla with Transnasal and
Zygomatic implants. <bold>Case report:</bold> Female patient, 70 years
old, with a 30-year history of total maxillary edentulism, with severe
bone resorption that made rehabilitation with conventional dental
implants impracticable. Through virtual planning, adequate conditions
were found for the placement of zygomatic implants on the left side, but
the right side had insufficient bone availability. Bone availability was
observed in the region of the right inferior turbinate and frontal
process of the maxilla, for the placement of a Transnasal implant. The
rehabilitation was performed with 3 zygomatic implants and 1 transnasal
implant, with composite torque of the implants, greater than 230Ncm,
allowing immediate installation of the abutments. A definitive acrylic
prosthesis was installed 5 days after surgery, with local edema already
controlled, facilitating installation. The patient has 13 months of
follow-up without peri-implant alterations, with the implants
osseointegrated and her dental occlusion reestablished.
<bold>Conclusion:</bold> The Transnasal Implant may be an auxiliary
option for the total rehabilitation of the atrophic maxilla. Virtual
planning with computed tomography to analyze local anatomical
conditions, such as adequate bone availability, are essential to
guarantee the success of the technique and reduce the chances of
problems related to the installation of transnasal implants.</p>
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<sec id="highlights">
  <title>Highlights</title>
  <p>1- The Transnasal Implant can be an option in the rehabilitation of
  the atrophic maxilla. 2- Bone grafts can considerably increase the
  morbidity and cost associated with the rehabilitation of the atrophic
  maxilla. 3- The use of bone anchorage techniques such as zygomatic,
  transnasal, palatal approach and pterygoid implants reduces
  rehabilitation time, procedure costs, increases the chances of
  immediate loading and has high success rates.</p>
</sec>
<sec id="introduction">
  <title>Introduction</title>
  <p>The rehabilitation of atrophic maxillae with dental implants is a
  complex procedure that involves several variables such as: Possibility
  of immediate loading, degree of bone resorption lack of bone volume,
  low bone density, pneumatization of the maxillary sinus, need for bone
  reconstruction, among others, making the procedure a real challenge
  for surgeons.
  Cawood and Howell 1988, defined the concepts for the classification of
  edentulous jaws, and how bone resorption occurs over time. The maxilla
  can be considered atrophic, in class IV, V and VI cases, where there
  is significant bone loss in thickness, and or thickness and height,
  generally requiring bone reconstruction through bone grafts, or the
  use of more advanced techniques such as zygomatic, Trans-sinusal or
  pterygoid implants.
  </p>
  <p>Maxillary reconstruction with bone grafts is an option for
  rehabilitation with dental implants. This reconstruction can be
  performed using intra or extra oral autogenous bone grafts, or
  biomaterials, however, depending on the technique, it can involve
  greater morbidity, unpredictable bone resorption, increase treatment
  costs, and a long rehabilitation time with several surgical steps,
  since in general, it is not possible to carry out immediate loading.
  Immediate loading is a desirable situation when rehabilitating
  atrophic jaws, especially because it significantly reduces total
  treatment time and costs. However, performing immediate loading on a
  grafted maxilla is quite complex since the newly inserted or even
  reconstructed bone does not present adequate density for the immediate
  function of the implants. In contrast to bone grafting, Maló et al
  2005 published a retrospective study with a 1-year follow-up in which
  they described the All-on-4 technique. This technique, in short,
  consists of installing conventional implants in the maxilla, with the
  two anterior axial implants, and the two posterior titled implants,
  bordering the maxillary sinus, with success rates exceeding 98 percent
  . Later variations of the technique emerged to solve other clinical
  situations, such as the All-on-4 Hybrid, where the posterior implants
  are zygomatic, and the All-on-4 zygoma (Quad Zygoma), where 4
  zygomatic implants are installed to perform the rehabilitation,
  demonstrating success rates similar to those of traditional All-on-4.
  Although the Zygomatic implants are an excellent option for cases of
  severe bone resorption, with low morbidity and low complication rates,
  however, they may present some important limitations for their
  execution, especially in the Quad Zygoma technique, such as: Small
  zygoma, implant path close to the infra-orbital foramen, orbital
  cavity with large volume, a large part of the implant passes
  internally to the maxillary sinus and concavity in the anterior region
  of the maxilla, making positioning of the anterior implant difficult.
  Another option to rehabilitate the atrophic maxilla is the use of
  Extra-Long dental implants. Maló et al 2013 classified extra-long
  implants with lengths between 20-25mm, used especially to guarantee
  immediate loading, when the zygomatic implant is contraindicated or
  simply not an option for the professional either reduce it as much as
  possible or avoid cantilevers in dental prostheses. Extra-long
  implants showed a high success rate, proving to be a viable option for
  this type of rehabilitation. Pterygoid and trans-sinusal implants are
  examples of techniques where extra-long implants can be used, seeking
  areas of bone anchorage distant from the base of the maxillary bone,
  generally with bone of greater density and allowing immediate loading.
  Thinking about alternatives to rehabilitate the atrophic maxillae, the
  Transnasal implant technique could be another option, and unlike
  pterygoid or trans-sinus implants, transnasal implants are placed in
  the anterior region of the maxilla. In this technique, the implants
  are placed with their path through the lateral wall of the piriform
  process and having their apical anchorage in the frontal process of
  the maxilla or at the level of the inferior turbinate, in a dense bone
  and with a great possibility of immediate loading.
  Camargo et al 2019, determined that for the installation of the
  Transnasal implant it is necessary to have at least 4mm of height
  between the ridge crest and the floor of the nasal cavity and at least
  3mm of apical bone in the frontal process of the maxilla or in the
  inferior turbinate so that there would be adequate stability of the
  implant and immediate loading was carried out. It is important to note
  that many patients have a good amount of bone in the region of the
  inferior turbinate, which can allow good bone anchorage, however there
  is no standard for this thickness. The choice of technique must always
  be made through virtual planning with computed tomography, which can
  accurately determine the precision of implant installation in this
  region. Preoperative visualization in biomodels is also recommended.
  The aim of this article is to report a case of rehabilitation of an
  extremely atrophic maxilla with extra-long Transnasal implants and
  zygomatic implants.
  </p>
</sec>
<sec id="case-report">
  <title>Case Report</title>
  <p>Patient female, 70 years old, non-smoker with no systemic diseases
  with complete upper edentulism and had been using a removable total
  prosthesis for around 30 years. Clinical and tomography examination,
  showed extreme maxillary bone atrophy, with absence of alveolar bone
  in zones 1 (anterior maxilla), 2 (premolars) and 3 (molars) of the
  maxilla for rehabilitation with conventional implants. Digital
  planning was then carried out (ImplantViewer®, Brazil) with the
  possibility of installing Zygomatic or Transnasal as an option for
  oral rehabilitation, however, the region of the frontal process of the
  maxilla, and inferior turbinate on the right side presents good bone
  availability ( (Figure 1 A), the region of the frontal process of the
  left maxilla did not have good bone availability, because there was
  pneumatization of the left maxillary sinus in the area, limiting the
  installation of the transnasal implant in the left size (Figure 1 B).
  </p>
  <fig id="fig_1">
    <caption><p>In A: Sagittal image of the computed tomography of the
    region for installation of the right Transnasal implant, showing
    adequate bone dimensions; In B: Sagittal image of the computed
    tomography of the region for the installation of the left Transnasal
    implant, showing the pneumatization of the maxillary sinus, making
    the installation of the implant unfeasible; In C: Axial section with
    the distance between the anterior wall of the frontal process of the
    right maxilla and the nasolacrimal duct.</p></caption>
    <graphic mimetype="image" mime-subtype="jpeg" xlink:href="Figure+1.jpeg" xlink:title="" />
  </fig>
  <p>In the tomographic examination, it was possible to observe the
  appropriate conditions for the installation of the right transnasal
  implant, as well as a safe distance (&gt;5mm) from the anterior wall
  of the frontal process of the maxilla to the nasolacrimal duct,
  avoiding injuries to this anatomical structure in the transoperative
  period, which are the main contraindications of the technique (Figure
  1 A and C). The right zygomatic bone was small, making it difficult to
  install the second zygomatic implant and consequently the Quad Zygoma
  technique, furthermore, there was a concavity in the maxilla in that
  region that made it difficult to correctly position the zygomatic
  implant. (Figure 2A). It was decided together with the patient to
  place one Transnasal implant (right side) and three zygomatic implants
  for rehabilitation with implant-supported prosthesis (Figure 2B), in a
  hospital environment under general anesthesia.
  </p>
  <fig id="fig_2">
    <caption><p>In A: Three-dimensional reconstruction of the tomography
    with planning for implant installation; In B: Distribution of
    Implants.</p></caption>
    <graphic mimetype="image" mime-subtype="jpeg" xlink:href="Figure+2.jpeg" xlink:title="" />
  </fig>
  <sec id="surgical-technique-transnasal-technique">
    <title>Surgical technique (Transnasal Technique) </title>
    <p>Nasotrancheal intubation was performed to use a surgical guide
    during surgery. The surgical guide used was created by duplicating
    the upper removable total prosthesis used by the patient, with the
    aim of verifying the anteroposterior position of implant placement.
    A full-thickness mucoperiosteal incision was made on the maxillary
    ridge with a palatinized incision, and relaxing incisions were made
    in the region of the zygomatic buttress bilaterally and in the
    midline. For the installation of Transnasal dental implant, the
    floor of the nasal cavity and the side wall of the pyriform process
    were gently detached so as not to lacerate the membrane.
    Instrumentation was performed through the residual alveolar ridge,
    with a slightly palatinized approach, with 800 RPM, towards the
    frontal process of the maxilla (Figure 3A). The visualization of the
    entry point of the inferior turbinate is crucial for instrumentation
    and subsequent implant placement (Figure 3B).
    </p>
    <fig id="fig_3">
      <caption><p>In A: Positioning of the initial drill for the
      preparation of the surgical socket.; In B: Bone drilling towards
      the frontal process of the maxilla; In C: Transnasal implant
      installation and final positioning.</p></caption>
      <graphic mimetype="image" mime-subtype="jpeg" xlink:href="Figure+3.jpeg" xlink:title="" />
    </fig>
    <p>A Transnasal implant, (Epikut Long Plus® SIN Implant System®,
    Brazil), 3.8mmx 24mm was placed with torque greater than 45Ncm
    (Figure 3C). The zygomatic implants (Helix GM® Zygoma Neodent®,
    Brazil) were placed, with torques greater than 60Ncm. (Figure 4A).
    45 degrees prosthetic abutments were installed, and a small amount
    of particulate bovine bone graft (Cerabone® Botiss®) is placed
    between the implant and the membrane of the detached nasal cavity,
    avoiding contact between the membrane and the implant, and possible
    fenestration of the implant in the nasal cavity later (Figure 4B).
    The prosthesis was installed five days after surgery.</p>
    <fig id="fig_4">
      <caption><p>In A: Intraoperative image after installation of the
      zygomatic implants and transnasal implant; In B: Biomaterial
      placed in the nasal cavity to prevent the implant from contacting
      the nasal membrane.</p></caption>
      <graphic mimetype="image" mime-subtype="jpeg" xlink:href="Figure+4.jpeg" xlink:title="" />
    </fig>
    <p>In the postoperative panoramic radiography, the excellent
    distribution of the implants was observed, with ideal conditions for
    rehabilitation with implant-supported prosthesis (Figure 5). the
    patient is in the 13th month post-operatively, and follow-up shows
    adequate peri-implant health, with lack of mobility of the implants,
    and reestablished dental occlusion and facial aesthetics.</p>
    <boxed-text>
      <graphic mimetype="application" mime-subtype="pdf" xlink:href="Figure+5.pdf" />
    </boxed-text>
  </sec>
</sec>
<sec id="discussion">
  <title>Discussion</title>
  <p>Total edentulism in the maxilla evolves with bone resorption and
  pneumatization of the maxillary sinus, which in severe cases may make
  it impossible to install dental implants, and anchorage techniques
  with Zygomatic, Transnasal or Pterygoid Implants are a highly
  predictable option, with high success rates and few associated
  complications.
  Bone reconstruction of the atrophic maxilla is a therapeutic
  rehabilitation option. However, the use of bone grafts presents some
  disadvantages in relation to anchorage techniques, with emphasis on
  the significant increase in treatment time, the need for several
  surgical steps until the installation of the prosthesis, and the
  impossibility in most cases of carrying out immediate loading.
  Thinking about immediate loading, this is a very important factor that
  we take into consideration when recommending bone anchorage
  techniques, since with immediate loading it is possible to install the
  prosthesis in up to 7 days fixed to the implants, increasing patient
  satisfaction in relation to the treatment and increasing their quality
  of life.
  Although zygomatic implants represent an excellent option in the
  rehabilitation of the edentulous maxilla, in cases of severe atrophy
  it is necessary to implement the Quad Zygoma technique, which can be
  complex to be performed in cases of narrow zygomas, infra-orbital
  nerve in the path of the implant and large maxillary concavity making
  it difficult to seat the implant in the bone and increasing the
  chances of gingival recession in this area, as the implant tends to be
  at the level of the alveolar crest, without bone insertion.
  Transnasal implants can be an option to avoid Quad Zygoma, in the
  cases mentioned above, or even as an option by the surgeon just to
  rehabilitate atrophic maxillae. Camargo et al 2021, published a study
  where 12 patients were rehabilitated with transnasal implants with a
  26-month follow-up, with a 100 percent success rate and immediate
  loading, showing that the technique is safe and clinically feasible.
  Other studies prove the effectiveness of the therapy with high success
  rates and no reported complications.
  A very important point in the Transnasal implant technique is digital
  planning using tomography using specific softwares. This step is
  essential because many patients do not have sufficient bone
  availability in the region to properly install the implant as
  indicated. Oh et al 2023, call “Z-Point”, the area between the nasal
  side and the lateral wall of the maxillary sinus at the level of the
  inferior turbinate. The authors state that this point is crucial for
  the installation of the Transnasal implant, with many patients having
  sufficient thickness and density for the installation of the implant.
  However, they state that only with tomography is it possible to
  accurately visualize this anatomical condition.
  Although current studies have not reported complications, it is
  important to remember that this is a sensitive and accurate technique
  that must be performed by experienced professionals. Furthermore, it
  is observed in the literature that the technique is recent, and with
  scientific evidence limited to a few case reports and retrospective
  studies, with short follow-up. For this reason, the results presented
  in this article and in current literature should be viewed with
  caution.
  Although published studies on transnasal implants did not report
  complications or even loss of implants, the complex anatomy of the
  region where the implant is installed must be taken into
  consideration. Without a doubt, the main anatomical structure to be
  observed when planning and executing the technique is the nasolacrimal
  duct. Injuries to this structure can lead to epiphora and require
  complex surgical treatment. To minimize the chances of injury to the
  nasolacrimal duct, digital tomographic planning is essential. Simmen
  et al 2017, carried out a tomographic study with 100 patients,
  evaluating the distance between the anterior wall of the maxilla at
  the level of the frontal process of the maxilla and the nasolacrimal
  duct. The authors concluded that 56.5 percent of patients have this
  distance between 7 and 3 mm, 12.5 percent have a distance greater than
  7 mm and 31.5 percent of patients have a distance of less than 3 mm.
  It is important to highlight that Camargo et al 2019 defined a safe
  parameter of at least 5mm distance, with the aim of avoiding injuries
  to the nasolacrimal duct, therefore prior planning and measurement of
  this distance are essential to prevent complications, as carried out
  in the present clinical case.
  Thinking specifically about the future of the technique and minimizing
  possible complications, some authors have been working with the
  piezoelectric system. The advantages are interesting, as piezo wears
  only the bone tissue, preserving adjacent structures such as the
  nasolacrimal duct and the membrane of the nasal cavity. The bone
  preparation for implant is carried out using specific tips, providing
  greater safety to the surgeon. This technology should certainly be
  applied with more emphasis in the coming years, minimizing the chances
  of complications inherent to the surgical technique.
  As previously mentioned, prior tomographic evaluation is essential for
  the installation of transnasal implants, however, a prior evaluation
  of the nasal cavity must also be carried out. The technique should be
  avoided in patients with a very wide nasal cavity, in which there is
  no contact between the implant and the lateral wall of the nasal
  cavity. Sahin et al 2023 claims that this may affect nasal function in
  some way, however, no changes in nasal function related to transnasal
  implants have been found in the available literature.
  As reported, the Transnasal implant can be an important option to help
  in the rehabilitation of the atrophic maxilla, especially in cases
  where it is not possible or desirable to install a conventional or
  zygomatic implant in the anterior region of the maxilla, however
  scientific evidence at the moment still presents limitations, and it
  is necessary prospective controlled studies, with a greater number of
  cases and longer follow-up time are necessary to determine the safety
  and efficacy of the technique in the long term.
  </p>
</sec>
<sec id="conclusion">
  <title>Conclusion</title>
  <p>Transnasal implants are viable options for the rehabilitation of
  the atrophic maxilla. Virtual planning, detailed tomographic analysis,
  surgical expertise and adequate prosthetic management are essential to
  guarantee the success of the technique and avoid intra- and
  postoperative complications.</p>
  <sec id="funding-statement">
    <title>Funding Statement</title>
    <p>This study did not receive any specific grants or aid from
    funding agencies in the public, commercial, or non-profit
    sectors.</p>
  </sec>
  <sec id="competing-interests">
    <title>Competing Interests</title>
    <p>None of the authors of the manuscript has any conflict of
    interest related to this study.</p>
  </sec>
  <sec id="consent-for-publication">
    <title>Consent For Publication</title>
    <p>The patient consented to the exposure of his images in this
    article, through an informed consent form.</p>
  </sec>
</sec>
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